منابع مشابه
Vesicle biogenesis potentiation
n recent years, scientists have found evidence that new neurons arise in the brains of adult mammals, but little is known about the underlying mechanisms. Now, on page 209, Kowalczyk et al. find that in neurogenic regions of the adult brain only one cy-clin D protein, cyclin D2, is required for neural precursors to enter the cell cycle. To determine which cyclins were required for adult neuroge...
متن کاملSynaptic vesicle biogenesis.
Synaptic vesicles, which have been a paradigm for the fusion of a vesicle with its target membrane, also serve as a model for understanding the formation of a vesicle from its donor membrane. Synaptic vesicles, which are formed and recycled at the periphery of the neuron, contain a highly restricted set of neuronal proteins. Insight into the trafficking of synaptic vesicle proteins has come fro...
متن کاملVesicle biogenesis: The coat connection
Membranes of the exocytic and endocytic transport pathways are endowed with the ability to generate 50-150 nm diameter vesicles that carry cargo between different cellular compartments. Vesicle formation requires the association of cytosolic coat proteins with the membrane, and the first discernible morphological change in the membrane is the appearance of small coated buds. These buds eventual...
متن کاملVti1a functions in dense-core vesicle biogenesis
The SNARE-protein Vti1a is proposed to drive fusion of intracellular organelles, but recent data also implicated Vti1a in exocytosis. Here we show that vti1a is absent from mature secretory vesicles in adrenal CCs, but localizes to a compartment near the Trans-Golgi-Network, partially overlapping with Syntaxin6. Exocytosis is impaired in vti1a null cells, partly due to fewer Ca-channels at the ...
متن کاملRole of clathrin in dense core vesicle biogenesis
The dense core vesicles (DCVs) of neuroendocrine cells are a rich source of bioactive molecules such as peptides, hormones, and neurotransmitters, but relatively little is known about how they are formed. Using fractionation profiling, a method that combines subcellular fractionation with mass spectrometry, we identified ∼1200 proteins in PC12 cell vesicle-enriched fractions, with DCV-associate...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1672iti1